Archive for the ‘Ovarian Cancer’ Category

Ovarian Cancer – Treatment and Prognosis

Saturday, March 14th, 2009

Treatment

Surgery is the preferred treatment and is frequently necessary for diagnosis. Studies have shown that surgery performed by a specialist in gynecologic oncology results in a higher rate of cure. Chemotherapy is used as after surgery to treat any residual disease. Chemotherapy can also be used to treat women who have a recurrence. Radiation therapy is rarely used in ovarian cancer in the United States.
Expectations (prognosis)

Ovarian cancer is disproportionately deadly for a number of reasons. First, symptoms are vague and non-specific, so women and their physicians frequently attribute them to more common conditions. By the time the cancer is diagnosed, the tumor has often spread beyond the ovaries.

Also, ovarian cancers shed malignant cells that frequently implant on the uterus, bladder, bowel, and lining of the bowel wall (omentum). These cells can begin forming new tumor growths before cancer is even suspected.

Second, because no cost-effective screening test for ovarian cancer exists, more than 50 percent of women with ovarian cancer are diagnosed in the advanced stages of the disease.

Ovarian cancer is rarely diagnosed in its early stages; it is usually quite advanced by the time diagnosis is made. The outcome is often poor. The five-year survival rate for all stages is only 35 percent to 38 percent. If, however, diagnosis is made early in the disease, five-year survival rates can reach 90 percent to 98 percent. Germ Cell Ovarian Cancer has a much better prognosis, but is rarer.

Despite this poor prognosis, patients should keep in mind that all such studies are retrospective in nature: ie, they can only look into past results. Therefore they cannot take into account the benefits on survival that newer therapies may provide.
Complications

* spread of the cancer to other organs
* progressive function loss of various organs
* ascites (fluid in the abdomen)
* blockage of the intestines

Ovarian Cancer – Classification and Staging

Tuesday, January 20th, 2009

Ovarian cancer is a malignant ovarian neoplasm (an abnormal growth located on the ovaries).

Classification

Ovarian cancer is classified according to the histology of the tumor. Lesions differ significantly in clinical features, management, and prognosis:

* Epithelial ovarian tumors are the most common and prototypic ovarian cancers. They are thought to originate from the ovarian surface lining, including the serous cystadenocarcinoma, and the mucinous cystadenocarcinoma.
* Stromal ovarian cancer includes lesions that are hormonally active such as the estrogen-producing granulosa cell tumor and the virilizing arrhenoblastoma.
* Germ cell cancer originates from dysplastic germ material and tends to occur in young women and girls. Lesions include the dysgerminoma, a form of the choriocarcinoma, and the malignant form of the teratoma.
* Other lesions include metastasis to the ovary, for instance from breast cancer. Krukenberg cancer is ovarian cancer originating from gastrointestinal cancer.

Staging

Ovarian cancer staging is by the FIGO staging system and uses information obtained after surgery, which should include a total abdominal hysterectomy, removal of (usually) both ovaries and fallopian tubes, (usually) the omentum, and pelvic (peritoneal) washings for cytology. The AJCC stage is the same as the FIGO stage.

* Stage I – limited to one or both ovaries
o IA – involves one ovary; capsule intact; no tumor on ovarian surface; no malignant cells in ascites or peritoneal washings
o IB – involves both ovaries; capsule intact; no tumor on ovarian surface; negative washings
o IC – tumor limited to ovaries with any of the following: capsule ruptured, tumor on ovarian surface, positive washings
* Stage II – pelvic extension or implants
o IIA – extension or implants onto uterus or fallopian tube; negative washings
o IIB – extension or implants onto other pelvic structures; negative washings
o IIC – pelvic extension or implants with positive peritoneal washings
* Stage III – microscopic peritoneal implants outside of the pelvis; or limited to the pelvis with extension to the small bowel or omen tum
o IIIA – microscopic peritoneal metastases beyond pelvis
o IIIB – macroscopic peritoneal metastases beyond pelvis less than 2cm in size
o IIIC – peritoneal metastases beyond pelvis > 2 cm or lymph node metastases
* Stage IV – distant metastases

Para-aortic lymph node metastases are considered regional lymph nodes (Stage IIIC).